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CRP (C-Reactive Protein) Test

Up to date🔬 Evidence: StrongInternal Medicine
Diğer adları: C-reactive protein, CRP level, High-sensitivity CRP
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Discuss your test results with your doctor. This page is for informational purposes only and does not provide a diagnosis.

Key Facts

• A protein produced by the liver in response to inflammation, infection, and tissue damage • Non-specific — may rise in many different conditions • Standard CRP evaluates acute inflammation; hs-CRP assesses low-grade chronic inflammation and cardiovascular risk • Normal standard CRP: <5 mg/L

🧪 What Does This Test Measure?

The CRP test measures C-reactive protein, produced by the liver in response to inflammation, infection, and tissue damage throughout the body.

📋 Why Is It Ordered?

Ordered for infection and inflammation evaluation, monitoring treatment response, autoimmune disease follow-up, and cardiovascular risk assessment (hs-CRP).

🔧 Preparation

CRP testing generally requires no special preparation. Fasting is not required.

📊 Reference Ranges

Standard CRP: Normal: <5 mg/L (some labs: <10 mg/L) Mild: 10–40 mg/L Moderate: 40–200 mg/L Severe: >200 mg/L hs-CRP (cardiovascular risk): <1 mg/L: low risk 1–3 mg/L: moderate risk >3 mg/L: higher risk

⬆️ High Values

Elevated CRP may be associated with bacterial infection, autoimmune disease, tissue damage, or postoperative inflammation. Mild elevations may be associated with obesity, smoking, or chronic conditions.

⬇️ Low Values

Low CRP generally suggests the absence of active inflammation or infection. Low hs-CRP is considered favorable for cardiovascular risk.

⚙️ What Can Affect Results?

Obesity, smoking, medications, physical activity, sleep quality, and acute infections are key factors that may affect CRP results.

🔬 Evidence Summary

Strong evidence: 2 guidelines, 1 meta-analysis, 1 clinical trial (RCT), 3 reviews.

Key Takeaways

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What you learned: CRP is a non-specific marker of inflammation and infection; an elevated result does not establish a diagnosis on its own. Standard CRP is used for acute conditions; hs-CRP is used for cardiovascular risk assessment.

A CRP result alone cannot diagnose infection, inflammation, or heart disease. Clinical context and supporting tests are needed.

🔬 Sources Used on This Page

8 sources · Most recent publication: 2024
📋
Guideline
Expert society and guideline recommendations
2
sources
📊
Systematic review / meta-analysis
Combined analysis of multiple studies
1
source
🔬
Clinical trial (RCT)
Controlled research conducted in humans
1
source
📖
Review
Comprehensive topic evaluation
4
sources
Overall assessment: Evidence level for this topic is strong. This page is supported by 2 guidelines, 1 systematic review/meta-analysis, 1 clinical trial, 4 reviews.

📝 Questions to Ask Your Doctor

Be prepared for your appointment. Add questions to your list.

Last reviewed: 3/26/2026
Next review: 6/26/2026

⚖️ Comparisons

CRP vs ESR

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⚖️ This page does not replace medical advice. Make treatment decisions with your doctor.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.