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eGFR (Estimated Glomerular Filtration Rate)

⚠️ Update approaching🔬 Evidence: ModerateInternal Medicine
Diğer adları: GFR, Glomerular filtration rate, Kidney filtration rate
⚠️

Discuss your test results with your doctor. This page is for informational purposes only and does not provide a diagnosis.

⚡ Key Facts

• A calculated value that estimates how well the kidneys filter blood per minute • Not a directly measured test — calculated from creatinine, age, and sex • ≥60 mL/min/1.73 m² is generally considered adequate • Used for CKD staging alongside albuminuria

🧪 What Does This Test Measure?

eGFR is a calculated value that estimates how well the kidneys filter blood per minute, derived from creatinine level, age, and sex using standardized formulas.

📋 Why Is It Ordered?

Ordered for kidney function evaluation, CKD staging, medication dose adjustment, risk assessment, and kidney disease monitoring.

🔧 Preparation

eGFR is not a direct test — it is calculated from a blood creatinine test. Therefore, preparation requirements for creatinine measurement apply.

📊 Reference Ranges

KDIGO CKD stages (eGFR, mL/min/1.73 m²): G1: ≥90 — Normal or high G2: 60–89 — Mildly decreased G3a: 45–59 — Mild to moderate decrease G3b: 30–44 — Moderate to severe decrease G4: 15–29 — Severely decreased G5: <15 — Kidney failure

⬆️ High Values

High eGFR generally indicates good kidney function. Physiological elevation occurs in pregnancy. In some cases, it may be associated with hyperfiltration.

⬇️ Low Values

Low eGFR may be associated with decreased kidney function. Chronic kidney disease, acute kidney injury, dehydration, or certain medications may contribute.

⚙️ What Can Affect Results?

Factors affecting eGFR are related to creatinine measurement: muscle mass, age, sex, diet, medications, and hydration. The formula used also matters.

🔬 Evidence Summary

Moderate evidence: 1 guideline, 2 landmark observational studies.

📚 Most Important Studies on This Topic

1

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Guideline· Kidney International · 2024 · PMID: 38490803

2

New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race

Observational· New England Journal of Medicine · 2021 · PMID: 34554658

3

A New Equation to Estimate Glomerular Filtration Rate

Observational· Annals of Internal Medicine · 2009 · PMID: 19414839

✅ Key Takeaways

💡

What you learned: eGFR is the most widely used indicator of kidney function. ≥60 mL/min/1.73 m² generally indicates adequate function; lower values are evaluated alongside albuminuria and clinical context.

⛔

A single eGFR value cannot diagnose kidney disease. Chronicity (≥3 months), albuminuria, and clinical context are needed.

🔬 Sources Used on This Page

3 sources · Most recent publication: 2024
📋
Guideline
Expert society and guideline recommendations
1
source
👁
Observational
Observational and cohort studies
2
sources
Overall assessment: Evidence level for this topic is moderate. This page is supported by 1 guideline, 2 observational studies.

📝 Questions to Ask Your Doctor

Be prepared for your appointment. Add questions to your list.

📋 References

[PMID: 38490803] KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, 2024.
[PMID: 34554658] New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. New England Journal of Medicine, 2021.
[PMID: 19414839] A New Equation to Estimate Glomerular Filtration Rate. Annals of Internal Medicine, 2009.
Last reviewed: 4/1/2026
Next review: 4/1/2027

⚖️ Comparisons

Creatinine vs eGFR→

🔗 Related Topics

🩺 Chronic kidney disease🧪 Kreatinin (eGFR girdisi)🧪 Üre (BUN)🧪 Açlık kan şekeri (diyabetik nefropati bağlamı)
⚖️ This page does not replace medical advice. Make treatment decisions with your doctor.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.