Home → Tests → GGT
GGT (Gamma-Glutamyl Transferase) Test
✅ Up to date🔬 Evidence: ModerateInternal Medicine
Diğer adları: Gamma-glutamyl transferase, Gamma-GT, GGT test
⚠️
Discuss your test results with your doctor. This page is for informational purposes only and does not provide a diagnosis.
⚡ Key Facts
• An enzyme concentrated in the liver and bile ducts
• Low specificity — may rise in many conditions
• Particularly useful for confirming liver origin of elevated ALP
• Sensitive to alcohol use
🧪 What Does This Test Measure?
The GGT test measures gamma-glutamyl transferase, a liver and bile duct enzyme that is particularly sensitive to alcohol use and cholestatic liver conditions.
📋 Why Is It Ordered?
Ordered to confirm liver origin of elevated ALP, evaluate alcohol-related liver damage, and assess metabolic syndrome-associated liver involvement.
🔧 Preparation
No special preparation is generally required. However, alcohol consumption may significantly elevate GGT and should be noted.
📊 Reference Ranges
Men: 8–61 U/L
Women: 5–36 U/L
⚠️ Reference ranges vary by laboratory.
⬆️ High Values
Elevated GGT may be associated with alcohol use, medications, metabolic syndrome, obesity, liver disease, or bile duct obstruction.
⬇️ Low Values
Low GGT is generally not clinically concerning and is often considered a favorable finding.
⚙️ What Can Affect Results?
Alcohol consumption, medications, body weight, metabolic status, age, sex, and physical activity may affect GGT results.
🔬 Evidence Summary
Moderate evidence: 2 guidelines, 1 meta-analysis.
✅ Key Takeaways
💡
What you learned: GGT is sensitive but not specific. It is most useful for confirming liver origin of ALP elevation and assessing alcohol-related liver effects.
⛔
A GGT result alone cannot diagnose liver disease. It should be interpreted alongside other liver tests and clinical context.
🔬 Sources Used on This Page
3 sources · Most recent publication: 2021📋
Guideline
Expert society and guideline recommendations
2
sources
📊
Systematic review / meta-analysis
Combined analysis of multiple studies
1
source
Overall assessment: Evidence level for this topic is strong. This page is supported by 2 guidelines, 1 systematic review/meta-analysis.
📝 Questions to Ask Your Doctor
Be prepared for your appointment. Add questions to your list.
Last reviewed: 4/1/2026
Next review: 7/1/2026
⚖️ Comparisons
🔗 Related Topics
🩺 Karaciğer hastalıkları🧪 ALT/AST (karaciğer enzimleri)🧪 Bilirubin🧪 ALP (alkalen fosfataz)
⚖️ This page does not replace medical advice. Make treatment decisions with your doctor.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.