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RDW (Red Cell Distribution Width)

Up to date🔬 Evidence: ModerateHematology
Diğer adları: RDW-CV, RDW test, Red cell distribution width
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Discuss your test results with your doctor. This page is for informational purposes only and does not provide a diagnosis.

Key Facts

• Measures the variation in red blood cell size (anisocytosis) • Normal: RDW-CV 11.5–14.5% • Helps distinguish iron deficiency (high RDW) from thalassemia trait (normal RDW) • Increasingly studied as a prognostic marker in various conditions

🧪 What Does This Test Measure?

RDW (red cell distribution width) measures the degree of variation in red blood cell sizes, helping distinguish iron deficiency anemia from thalassemia trait.

📋 Why Is It Ordered?

Ordered for anemia differential diagnosis, distinguishing iron deficiency from thalassemia, and monitoring nutritional deficiency treatment response.

🔧 Preparation

Part of the CBC. No special preparation is required.

📊 Reference Ranges

Normal: RDW-CV 11.5–14.5% Elevated: >14.5% (anisocytosis — red blood cell size variation) ⚠️ Reference ranges vary by laboratory.

⬆️ High Values

Elevated RDW may be associated with iron deficiency anemia, B12 or folate deficiency, hemolytic anemia, recent transfusion, or mixed nutritional deficiencies.

⬇️ Low Values

Low RDW is generally not clinically significant. It indicates homogeneous red blood cell sizes.

⚙️ What Can Affect Results?

Blood transfusion, post-iron treatment changes, sample storage time, cold agglutinins, and reticulocytosis may affect RDW results.

🔬 Evidence Summary

Moderate evidence: 1 guideline, 1 systematic review, and 3 reviews/observational studies.

Key Takeaways

💡

What you learned: RDW quantifies red blood cell size variation. It is particularly useful for distinguishing iron deficiency from thalassemia trait.

RDW alone cannot diagnose anemia type. It should be interpreted alongside MCV, iron panel, and clinical context.

🔬 Sources Used on This Page

5 sources · Most recent publication: 2024
📋
Guideline
Expert society and guideline recommendations
1
source
📊
Systematic review / meta-analysis
Combined analysis of multiple studies
1
source
📖
Review
Comprehensive topic evaluation
2
sources
👁
Observational
Observational and cohort studies
1
source
Overall assessment: Evidence level for this topic is strong. This page is supported by 1 guideline, 1 systematic review/meta-analysis, 2 reviews, 1 observational study.

📝 Questions to Ask Your Doctor

Be prepared for your appointment. Add questions to your list.

Last reviewed: 4/2/2026
Next review: 7/2/2026

⚖️ Comparisons

MCV vs RDW

🔗 Related Topics

🧪 MCV (ortalama eritrosit hacmi)🧪 Hemoglobin🧪 Hemogram (tam kan sayımı)🧪 Ferritin (demir depoları)
⚖️ This page does not replace medical advice. Make treatment decisions with your doctor.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.