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D-Dimer Test
✅ Up to date🔬 Evidence: StrongHematology
Diğer adları: D dimer, D-dimer level, Fibrin degradation product
⚠️
Discuss your test results with your doctor. This page is for informational purposes only and does not provide a diagnosis.
⚡ Key Facts
• A protein fragment released when blood clots break down
• Primarily used to rule out clotting events (DVT, PE)
• In an appropriate clinical setting, a normal result makes active clotting unlikely
• Many non-clot conditions can elevate D-dimer
🧪 What Does This Test Measure?
The D-dimer test measures a protein fragment produced when blood clots are broken down by the body's fibrinolytic system, primarily used to rule out DVT and pulmonary embolism.
📋 Why Is It Ordered?
Primarily ordered to rule out DVT and pulmonary embolism. Also used in DIC evaluation and monitoring of clotting disorders.
🔧 Preparation
Fasting is generally not required. A venous blood sample is collected. Result turnaround time may vary.
📊 Reference Ranges
Normal: <500 µg/L (FEU) or <250 µg/L (DDU)
Age-adjusted threshold (≥50 years): age × 10 µg/L (FEU)
⚠️ Units and thresholds vary by assay method.
⬆️ High Values
Elevated D-dimer may be associated with DVT, pulmonary embolism, DIC, or other clotting processes. Many non-clot conditions also elevate D-dimer.
⬇️ Low Values
A low or normal D-dimer level suggests that active clot formation and breakdown is unlikely. In an appropriate clinical setting, this makes active DVT/PE unlikely.
⚙️ What Can Affect Results?
Age, pregnancy, infection, surgery, cancer, anticoagulant medications, and assay method may affect D-dimer results.
🔬 Evidence Summary
Strong evidence: 3 guidelines, 1 systematic review, and 3 observational studies.
✅ Key Takeaways
💡
What you learned: D-dimer is primarily a clot exclusion test. A normal result makes active clotting very unlikely; an elevated result requires further investigation.
⛔
An elevated D-dimer alone does not confirm a clot. Imaging and clinical assessment are needed for diagnosis.
🔬 Sources Used on This Page
7 sources · Most recent publication: 2026📋
Guideline
Expert society and guideline recommendations
3
sources
📊
Systematic review / meta-analysis
Combined analysis of multiple studies
1
source
👁
Observational
Observational and cohort studies
3
sources
Overall assessment: Evidence level for this topic is strong. This page is supported by 3 guidelines, 1 systematic review/meta-analysis, 3 observational studies.
📝 Questions to Ask Your Doctor
Be prepared for your appointment. Add questions to your list.
Last reviewed: 4/2/2026
Next review: 7/2/2026
⚖️ Comparisons
🔗 Related Topics
🧪 CRP (C-reaktif protein)🧪 Hemogram (tam kan sayımı)🧪 PT/INR (protrombin zamanı)🧪 aPTT (aktive parsiyel tromboplastin zamanı)🧪 Fibrinojen
⚖️ This page does not replace medical advice. Make treatment decisions with your doctor.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.
Content is based on scientific studies indexed in PubMed and current clinical guidelines.